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Piperazine: first used as an anthelmintic in the 1950s and used to treat common roundworms and pinworms. Benzimidazoles: a class of anthelmintics first discovered in 1961 that includes thiabendazole, mebendazole, and albendazole used to treat roundworms. Pyrantel: a treatment for several types of intestinal worms, including pinworms, used since ...

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With albendazole, microfilaria counts also decrease slowly—over a period of months by 50% or more after a single oral dose of 400 mg. Albendazole also has activity against adult filarial worms. Treatment with high-dose albendazole (400 mg twice daily for 21 days) was effective for killing filarial worms, but this regimen caused an ...

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